22 Feb Is Hybrid Cooperative Complex Injectable Moisturiser the Injectable Skincare of the Future?
Hybrid Cooperative Complex Injectable Moisturiser: The Insider’s Review to the Future of Injectable Skincare.
You’ve heard about oral skincare, printable skincare but what about injectable skincare? Injectable skincare isn’t exactly new- Skinboosters and PDRN Skinboosters are two very popular skin hydration and collagen building treatments in Singapore that are regarded as injectable moisturisers. Now you can add one more name to your vocabulary of injectable skincare: Hybrid Cooperative Complex Injectable Moisturiser.
Related blogpost:
Is Skinvive Better than Hybrid Cooperative Complex Injectable Moisturiser?
PDRN Skinboosters: What You Must Know Before Getting It
For beauty insiders and readers who are clued in with European aesthetic trends, Hybrid Cooperative Complex Injectable Moisturiser might sound very familiar. It is THE skin hydration and anti-wrinkle treatment of the moment in Europe and has been reviewed by many beauty writers. Hybrid Cooperative Complex Injectable Moisturiser has even been called “The the anti-wrinkle treatment for 2019” by The Times, a British newspaper. The question that’s on everyone’s mind right now is: is Hybrid Cooperative Complex Injectable Moisturiser worth it? To answer this question, let’s first get down to the science and biochemistry of this bioremodelling injectable.
The breakthrough that sets Hybrid Cooperative Complex Injectable Moisturiser apart from the current realm of injectable skin hydrating treatments is its patented technology that remodels the skin for younger and healthier skin. Unique to Hybrid Cooperative Complex Injectable Moisturiser is its molecular structure that stimulates the formation of collagen, elastin and stem cells for healthier and younger skin1,2.
If injectable treatments like Botulinum toxin and dermal fillers worry you about overly filled and frozen faces, rest assured that you will not go down that route with this treatment. Technically speaking, Hybrid Cooperative Complex Injectable Moisturiser is much more than an injectable moisturiser. More correctly speaking, it is a bio-remodelling tissue stimulator that goes deeper into the skin to smoothen and tighten skin, while hydrating the skin from within3,4.
Excited to know more about the future of injectable moisturisers? Here’s the lowdown on all you need to know about this new bioremodelling treatment that looks set to be a game changer for injectable moisturisers.
Hybrid Cooperative Complex Injectable Moisturiser increases the amount of elastin formation in the skin. The green stains in the diagrams are the elastin fibres expressed by Hybrid Cooperative Complex Injectable Moisturiser vs controls and other forms of hyaluronic acid in an in-vitro study.
First up, what is Hybrid Cooperative Complex Injectable Moisturiser?
Hybrid Cooperative Complex Injectable Moisturiser (逆時針) is an anti-aging injectable treatment that contains hyaluronic acid for skin rejuvenation, hydration and elasticity. The unique molecular structure of Hybrid Cooperative Complex Injectable Moisturiser stimulates the formation of 4 types of collagen, elastin and proliferate adipocytes (fat) stem cells causes bioremodelling of the skin while hydrating skin from within.
A study involving 15 patients showed that the patients experienced improvements in skin hydration and elasticity.
What are the benefits of Hybrid Cooperative Complex Injectable Moisturiser treatment injections to the skin?
• Improved skin hydration
• Healthier and firmer skin
• Faster wound healing
• Lifting effect and tighter skin
• Smoother skin
• Reduced depth of depressed scars (e.g. from acne scars and chicken pox) can be made shallower
Hybrid Cooperative Complex Injectable Moisturiser contains a high concentration of high and low molecular weight hyaluronic acid.
What does Hybrid Cooperative Complex Injectable Moisturiser contain?
Hybrid Cooperative Complex Injectable Moisturiser contains a mixture of high and low molecular weight hyaluronic acid molecules. The concentration of hyaluronic acid in Hybrid Cooperative Complex Injectable Moisturiser is 64mg/2ml (or 32mg/ml)- higher than the concentration of hyaluronic acid in most dermal fillers.
You might be familiar with hyaluronic acid- it is a familiar feature in dermal fillers and skincare for its hydrating prowess. In Hybrid Cooperative Complex Injectable Moisturiser, the low molecular weight hyaluronic acid allows for a slow and sustained release of hyaluronic acid which causes bioremodelling and reduced inflammation. The high molecular weight hyaluronic acid reinforces the framework and scaffolding of hyaluronic acid in the skin for the lifting (i.e. bioremodelling) effect3,4.
Related blogpost:
Everything You Need to Know About Hyaluronic Acid
What’s new and interesting about Hybrid Cooperative Complex Injectable Moisturiser?
Just in case you’re a little confused about Hybrid Cooperative Complex Injectable Moisturiser treatments because of its similarities to Skinboosters and dermal fillers because all of them contain hyaluronic acid; that’s really where the similarities end. Hybrid Cooperative Complex Injectable Moisturiser is neither a dermal filler nor Skinbooster treatment. It is a bioremodelling skin treatment that rejuvenates collagen and elastin formation in the skin.
No BDDE or chemical cross links
Besides the high concentration and mixture of low and high molecular weight hyaluronic acid; Hybrid Cooperative Complex Injectable Moisturiser does not contain chemical cross links or BDDE (1,4-Butanediol Diglycidyl Ether). BDDE is a common feature in Skinboosters and dermal fillers for increased stability and biomechanics. BDDE has been linked to a slightly increased risk of inflammation and formation of lumps in the skin, however BDDE in general in dermal fillers and Skinboosters is very safe5.
Less inflammation and higher spreadability with Hybrid Cooperative Complex Injectable Moisturiser treatment
Although there are no chemical cross links or BDDE in Hybrid Cooperative Complex Injectable Moisturiser, the hyaluronic acid complexes are stabilised through thermal cross links. Hybrid Cooperative Complex Injectable Moisturiser’s patented NAHYCO® Technology binds the high and low molecular weight hyaluronic acid through thermal cross-linking to form Hybrid Cooperative Complex Hyaluronic Acid. This complex allows for lower inflammatory response, low viscosity and high spreadability6. This translates to better safety, lesser injection points and faster recovery for patients.
This hybrid complex of hyaluronic acid also tightens, hydrates and rejuvenates skin by kickstarting collagen and elastin at different depths of the skin.
Hybrid Cooperative Complex Injectable Moisturiser treatment also recruits adipocyte stem cells and enhances renewal of cells1,2. The high molecular weight hyaluronic acid in Hybrid Cooperative Complex Injectable Moisturiser injections maintains optimal conditions for viability of the adipocyte stem cells for remodelling of the skin for better elasticity and support.
Hybrid Cooperative Complex Injectable Moisturiser also contains one of the highest concentrations of hyaluronic acid to up the ante for skin hydration.
These are some of the findings of the benefits that I find very useful, especially since of these benefits are not achieved with other anti-aging treatments.
How does Hybrid Cooperative Complex Injectable Moisturiser work1-4?
There are 2 parts to this answer. The mixture of high and low molecular weight hyaluronic acid molecules hydrate the skin due to their hydrophillic nature, similar to Skinboosters.
Related blogpost:
Skinboosters- All You Need to Know About It
Secondly, this complex of stabilised hyaluronic acid is slowly released in the skin and acts on different layers of the skin to stimulate the fibroblasts, keratinocytes and adipocytes for healthier skin. This then effects the changes and benefits to the skin as mentioned above.
Aug 2026 Update: A new injectable with an even higher hyaluronic acid content and different benefits, called Hybrid Cooperative Complex for Structure. I share more in New Injectable Updates from Europe: Hybrid Cooperative Complex for Structure is now available in Singapore
Where is Hybrid Cooperative Complex Injectable Moisturiser from?
Hybrid Cooperative Complex for Structure is from Italy and it has been commercially available in Europe since 2015. The manufacturer of Hybrid Cooperative Complex Injectable Moisturiser is IBSA Farmaceutici Italia .
Performing Hybrid Cooperative Complex Injectable Moisturiser injections in my clinic in Singapore. There are immediate small bumps (swelling) after Hybrid Cooperative Complex Injectable Moisturiser injections which will disappear within 2 hours for most people.
Is Hybrid Cooperative Complex Injectable Moisturiser safe?
So far, Hybrid Cooperative Complex Injectable Moisturiser injection treatments have been shown to be safe3,4. Most patients report mild and temporary swelling related to the injections, rather than the ingredients of the product. Hyaluronic acid is safe to be injected in the skin and this has been confirmed by studies on Hybrid Cooperative Complex Injectable Moisturiser3,4.
There are some features in Hybrid Cooperative Complex Injectable Moisturiser treatment that improve the safety profile of the injections:
1. The absence of chemical cross links or BDDE for greater biocompatibility in human skin. This also lower the risk of inflammation and formation of lumps under the skin with Hybrid Cooperative Complex Injectable Moisturiser injections.
2. The injection points for Hybrid Cooperative Complex Injectable Moisturiser are less than Skinboosters and Rejuran; which means a lower risk of side effects and complications such as bruising and (very rarely) infections.
3. The injection points for Hybrid Cooperative Complex Injectable Moisturiser are also standardised- 5 injection points called Bio Aesthetic Points (BAP)3,4,7; which are far from major nerves and blood vessels; so risk of injury to these structures is much lower.
Who is suitable for Hybrid Cooperative Complex Injectable Moisturiser injections?
Hybrid Cooperative Complex Injectable Moisturiser is suitable for anyone who wants to improve skin hydration and correct mild to moderate signs of aging in the skin such as fine lines and mild sagging. This bioremodelling injectable can improve skin hydration, rejuvenation and tightening.
If you are looking for healthier and younger looking skin but you’re not keen for Botulinum toxin or dermal fillers, a bioremodelling injectable like Hybrid Cooperative Complex Injectable Moisturiser would be a good recommendation to eradicate your fine lines, gently lift your skin and improve your skin texture.
Related blogposts:
Is Botulinum toxin Deadly? 5 Things You Need to Know About Botulinum toxin Safety
Botulinum toxin vs Dermal Fillers: What Are the Differences?
Transepidermal water loss is also reduced with Hybrid Cooperative Complex Injectable Moisturiser injections. So if you have conditions such as eczema or dry skin due to increased transepidermal water loss, Hybrid Cooperative Complex Injectable Moisturiser treatment will be useful protecting your skin on top of your existing treatment(s).
Both male and female patients are suitable for Hybrid Cooperative Complex Injectable Moisturiser injections. This bioremodelling injectable does not change your facial features or shape so it will not make male patients feminine looking.
What are the side effects, downtime or complications of Hybrid Cooperative Complex Injectable Moisturiser injections?
Treatment with Hybrid Cooperative Complex Injectable Moisturiser is generally safe. The side effects are related to the injections itself rather than the ingredients in Hybrid Cooperative Complex Injectable Moisturiser. A study that reviewed the safety of Hybrid Cooperative Complex Injectable Moisturiser injections showed that temporary swelling and bruising were the main issues of discomfort3,4. There were no reported major complications such as arterial occlusion3,4.
Downtime associated with Hybrid Cooperative Complex Injectable Moisturiser injections is negligible. There are small bumps/swelling immediately after Hybrid Cooperative Complex Injectable Moisturiser injections that will disappear within 1-2 hours. Very rare, this very mild swelling may persist. Bruising is very uncommon as major vessesls are avoided as the specific injection points for Hybrid Cooperative Complex Injectable Moisturiser.
Are there limitations with Hybrid Cooperative Complex Injectable Moisturiser injections?
Although Hybrid Cooperative Complex Injectable Moisturiser treatment is an excellent skin hydrating and skin tightening, there are a few limitations. Hybrid Cooperative Complex Injectable Moisturiser lasts for 6 months and you might need to repeat it if you would like to see the benefits again.
If you’re looking to get Hybrid Cooperative Complex Injectable Moisturiser injections, the recommended protocol is to begin with 2 treatment sessions one month apart followed by maintenance 6 months after. However, if you have very dry skin, conditions such as eczema or more severe signs of aging, you might require more sessions for more obvious results. It’s best to discuss with your doctor about the treatment protocol that you may need for best results.
The other point that I have emphasised repeatedly- Hybrid Cooperative Complex Injectable Moisturiser is not a dermal filler is also particularly relevant here. Although both injectables contain hyaluronic acid as their main active ingredient; the biochemistry and injection techniques are very different. Correspondingly, the results of Hybrid Cooperative Complex Injectable Moisturiser vs dermal fillers are different. Hybrid Cooperative Complex Injectable Moisturiser is not capable of adding volume or sculpting the face the way dermal fillers can.
Related blogposts:
Under Eye/ Tear Trough Fillers
Nose fillers: 5 Things You Need to Know
Chin fillers: Jaw Botulinum toxin and chin filler review
Cheek fillers: All You Need to Know About Non-Surgical Cheek Augmentation
The skin tightening and gentle lifting effect of Hybrid Cooperative Complex Injectable Moisturiser also cannot be compared to a dedicated lifting treatment for sagging skin such as face threadlifts, dermalift or dermal filler (“Liquid Facelift”). Hybrid Cooperative Complex Injectable Moisturiser is also not an under eye filler for dark eye circle or under eye bags, which would require tear trough fillers. Although Hybrid Cooperative Complex Injectable Moisturiser can be injected close to the eyes for wrinkles; it is also does not remove crows’ feet wrinkles. Crows’ feet wrinkles at the outer corners of the eyes would require Botulinum toxin injections.
If you are looking to address these signs of aging- volume loss, sagging, skin laxity- you can consider combining Hybrid Cooperative Complex Injectable Moisturiser together with other treatments e.g. lasers
Are Hybrid Cooperative Complex Injectable Moisturiser injections painful?
There is some discomfort with Hybrid Cooperative Complex Injectable Moisturiser injections; as with all injections. In my clinic in Singapore, I usually prepare the patient by getting their face numbed before starting. This helps to reduce discomfort.
One advantage of Hybrid Cooperative Complex Injectable Moisturiser injections is that only 5 injection points are required on each side of the face and/or neck; as opposed to the numerous injections required for Skinboosters.
How often should I get Hybrid Cooperative Complex Injectable Moisturiser injections?
The recommended treatment protocol based on the studies conducted is to begin with 2 sessions one month apart followed by maintenance injections 6 months afterwards.
As I have explained under “Are there limitations with Hybrid Cooperative Complex Injectable Moisturiser injections?”, if you have more severe signs of aging or dry skin like eczema, you may require a third or fourth session to achieve optimal results before moving onto maintenance treatment.
How long do the results of Hybrid Cooperative Complex Injectable Moisturiser injections last?
There isn’t a consensus about how long the results of Hybrid Cooperative Complex Injectable Moisturiser injections last so far. The recommended treatment protocol is to repeat Hybrid Cooperative Complex Injectable Moisturiser injections 6 months after the initial treatment.
As with any treatment- be it Skinboosters, PDRN Skinboosters, Botulinum toxin or dermal fillers- the longevity may differ from person to person.
Hybrid Cooperative Complex Injectable Moisturiser vs PDRN Skinboosters
You might be confused by the differences between Hybrid Cooperative Complex Injectable Moisturiser vs PDRN Skinboosters because they seem a little similar. Allow me to demystify some of the differences between Hybrid Cooperative Complex Injectable Moisturiser vs PDRN Skinboosters.
PDRN Skinboosters is also used to treat conditions similar to Hybrid Cooperative Complex Injectable Moisturiser such as acne scars and signs of aging like wrinkles. To add to the confusion, some doctors and publications also refer to PDRN Skinboosters as an injectable moisturiser or skincare. Technically, that is not wrong as PDRN Skinboosters contains a small amount of hyaluronic acid that can hydrate the skin.
Unlike Hybrid Cooperative Complex Injectable Moisturiser where the active ingredients is a complex of high and low molecular weight hyaluronic acid, the main active ingredient in PDRN Skinboosters is polynucleotides (PN or PDRN) derived from salmon sperm.
Hybrid Cooperative Complex Injectable Moisturiser hydrates and bioremodels the skin by increasing the amounts of collagen and elastin in the skin. Stem cells in the skin are also activated by Hybrid Cooperative Complex Injectable Moisturiser. On the other hand, the polynucleotides in PDRN Skinboosters stimulate tissue repair, build collagen and reduce inflammation in the skin.
The injection techniques, treatment protocol and prices also differ for Hybrid Cooperative Complex Injectable Moisturiser vs PDRN Skinboosters. Hybrid Cooperative Complex Injectable Moisturiser is injected over 5 injection points on each side of the face and neck. PDRN Skinboosters is injected over more points over the face and neck; and it can be injected using an injector gun or manually with a needle. The recommended injection intervals are 1 month apart for the first 2 months for Hybrid Cooperative Complex Injectable Moisturiser followed by maintenance. For PDRN Skinboosters, the recommended injection intervals are one month apart for the first 3 months followed by maintenance.
Hybrid Cooperative Complex Injectable Moisturiser vs Skinboosters: What are the differences?
Both injectables contain hyaluronic acid and hydrate the skin. Hybrid Cooperative Complex Injectable Moisturiser has the additional advantage of bioremodelling the skin i.e. form 4 types of collagen and elastin; and proliferate adipocytes (fat) stem cells.
Hybrid Cooperative Complex Injectable Moisturiser also acts on different layers of the skin- the epidermis, dermis and superficial fat layer to regenerate the skin. Skinbooster acts on a single depth.
Hybrid Cooperative Complex Injectable Moisturiser VS Skinbooster
Does this mean Hybrid Cooperative Complex Injectable Moisturiser gives better results than Skinboosters?
Not really, Hybrid Cooperative Complex Injectable Moisturiser and Skinboosters have different strengths. The recommended treatment regime and cost of both treatments are also different.
Hybrid Cooperative Complex Injectable Moisturiser is most suitable for patients who want to treat skin dryness, mild skin laxity/ sagging and signs of aging like fine wrinkles. In my opinion, Skinboosters are best for patients who want to hydrate dry skin and achieve brighter and glowy skin and smaller pores.
Although the recommended treatment intervals and the number of injection points are less for Hybrid Cooperative Complex Injectable Moisturiser vs Skinboosters, Skinboosters seems to last longer than Hybrid Cooperative Complex Injectable Moisturiser. The cost of Hybrid Cooperative Complex Injectable Moisturiser vs Skinboosters is also different. With the total number of sessions taken into account, the price of Hybrid Cooperative Complex Injectable Moisturiser is still more than Skinboosters in Singapore.
Can I combine Hybrid Cooperative Complex Injectable Moisturiser injections with other treatments e.g. lasers, Skinboosters and PDRN Skinboosters?
Yes, it is safe to have these treatments combined. Hybrid Cooperative Complex Injectable Moisturiser injections alone are not able to completely eradicate wrinkles, lift the skin or replace volume loss. Hence, consider combining with other anti-aging treatments if you would like a more holistic approach to treating your skin.
My basic recommendation would be to combine Hybrid Cooperative Complex Injectable Moisturiser injections with Q-switched lasers to lighten pigmentation and brighten skin together! If you have specific concerns like wrinkles or volume loss, consider adding Botulinum toxin and dermal fillers!
Where else can Hybrid Cooperative Complex Injectable Moisturiser be injected into?
• Face
• Neck
• Hands
• Body: chest and abdomen
Related blogpost:
Hand Fillers: Turning Back the Hands of Time
So far the bio-aesthetic injection points have been standardised for the face and neck. The rest of the bio aesthetic injection points for the hands and bodies are being explored. You can see how I do Hybrid Cooperative Complex Injectable Moisturiser hand injections in Hand Rejuvenation With Hybrid Cooperative Complex Injectable Moisturiser Hand Treatments.
Aftercare for Hybrid Cooperative Complex Injectable Moisturiser injections: What do I need to avoid after Hybrid Cooperative Complex Injectable Moisturiser injections?
Avoid facials, massages or vigorous activity to the skin after injections. Please also avoid consuming alcohol, supplements that may worsen bruising such as gingko.
Conclusion on Hybrid Cooperative Complex Injectable Moisturiser and injectable skincare
I hope that you found this insider’s guide to Hybrid Cooperative Complex Injectable Moisturiser. Hybrid Cooperative Complex Injectable Moisturiser is a welcome addition to the family of injectable skincare and bioremodelling treatments in Singapore. the This review of Hybrid Cooperative Complex Injectable Moisturiser will be updated with more details soon. Please feel free to leave a comment or share this post!
References
1. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. Stellavato et al. PLoS One 2016;11:e0163510.
2.Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodelling. Stellavato et al. Cell Physiol Biochem 2017;44:1078-1092.
3. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Sparavigna and Tenconi. Clin Cosmet Investig Dermatol. 2016; 9: 297–305.
4. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes. Laurino et al. Eplasty. 2015; 15: e46.
5. A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether–Crosslinked Hyaluronic Acid Dermal Fillers. De Boulle et al. Dermatol Surg. 2013 Dec; 39(12): 1758–1766.
6. In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes. D’Agostino et al. BMC Cell Biol. 2015 Jul 11;16:19.
7. Hyaluronic acid hybrid cooperative complexes and the BAP (Bio Aesthetic Points) technique: the new edge in biorejuvenation. Beatiniet al. Aesthetic Medicine. 2016; 2(2); 45-51.
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