Beauty Trends

New Injectables from Europe: Profhilo Structura

11 May 2024



If you could stave off volume loss in your face without surgery or facial fillers, would you? A new aesthetic treatment launching in Singapore in 2025 may be the closest thing to restoring facial contours and facial fats. Profhilo Structura is the newest hyaluronic acid injectable moisturiser that was unveiled in 2024 in Europe. I was in Milan recently to visit the Agora School of Aesthetic Medicine, a post graduate institution that formalises training of plastic surgeons and dermatologists in Aesthetic medicine and surgery. During this visit, I had the opportunity to learn from Italian surgeons about expanding indications for Profhilo and Profhilo Structura ahead of its launch in Singapore!


Related blogposts:

Is Profhilo the Injectable Skincare of the Future?

Neck Profhilo to Lift, Tighten and Rejuvenate the Neck


An honour to have learnt from Italian plastic surgeon,Dr. Domenico Romano at the Agora School of Aesthetic Medicine in Milan.

Sharing the newest updates in Aesthetics medicine from Europe in this review before they arrive in Singapore!



Profhilo Structura 

What is Profhilo Structura?

Profhilo Structura is a new hyaluronic acid injectable from the makers of Profhilo, IBSA Pharma. Like its predecessor, Profhilo Structura also contains a high concentration of high and low molecular weight hyaluronic acid. This new product is designed to restore the fat tissues of the face, which naturally reduces as we get older.


What does Profhilo Structura contain?

Profhilo Structura contains 45 mg of low molecular weight hyaluronic acid and 45 mg of high molecular weight hyaluronic acid. This mixture is contained in a 2 mL syringe. Profhilo Structura also uses the same NAHYCO® Hybrid Technology as its predecessor, Profhilo. This means that Profhilo Structura’s mixture of high and low weight hyaluronic acid molecules are joined together without chemical cross links.

Profhilo Structura VS its predecessors.


What does Profhilo Structura do?

Profhilo Structura restores and respositions fat tissues in the face. This delays the natural age related volume loss and hollowness in the face. According to information from IBSA, Profhilo Structura allows the preservation of a natural look, and aesthetic effects similar to those obtained using crosslinked dermal fillers.


How is Profhilo Structura different from Profhilo?

Profhilo Structura has a higher hyaluronic acid content (90mg/2mL) than the original Profhilo (64mg/2mL); as well as different rheological characteristics. Profhilo Structura has been developed to restore the fat tissue layer; as opposed to being an injectable moisturiser like Profhilo.


The injection techniques for Profhilo Structura are also different from the original Profhilo.


With Dr. Editta Buttura, Maxillofacial surgeon to learn about Profhilo Structura.


When will Profhilo Structura be launched in Singapore? There is currently no news on Profhilo Structura’s launch in Singapore and Asia yet. Profhilo Structura will be launching in the UK and Europe in June 2024. I’m excited about Profhilo Structura, and will be updating this blogpost with more information gets released.


Many of us are familiar with Profhilo as an injectable moisturiser that’s classically injected in the cheeks; but the indications for Profhilo beyond this region i.e. forehead, temples and periorbital regions have expanded.


Profhilo 2.0: Expanding indications 

Termed Profhilo 2.0, treatment of the upper face with hyaluronic acid injections can improves skin hydration, texture and signs of ageing like wrinkles and loss of elasticity. As I’ve shared in great detail about the science and benefits of Profhilo in Is Profhilo the Injectable Skincare of the Future? , this treatment can be useful in stimulating collagen and elastin formation in the skin. Individuals who have acne scars, enlarged pores, sagging and wrinkles in the upper face can consider Profhilo 2.0 to treat these conditions.


I’m honored to have gained a sneak preview of Profhilo Structura ahead of its launch in Singapore; as well as to learn from Plastic Surgeon Dr. Domenico Romano and OMS surgeon Dr. Editta Buttura advanced injections for Profhilo. Till then, addios Milano!


A few of my favourites memories of Spring in Italy- heading out to the coast and beaches of Portofino and Bocadasse, beautiful magnolia blooms in Tirano, all the food and art in Milan!



1. Elucidations on the Performance and Reversibility of Treatment with Hyaluronic Acid Based Dermal Fillers: In vivo and in vitro Approaches. Scrima et al. Clin Cosmet Investig Dermatol. 2022 Dec 8:15:2629-2640.

2. Restoring Adipose Tissue Homeostasis in Response to Aging: Initial Clinical Experience with Profhilo Structura®. Cassuto et al. Gels. 2023 Jul 28;9(8):614.

3. Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: An observational pilot study. Sparavigna et al. Health Sci Rep. 2024 Jan 21;7(1):e1743.



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