Body Contouring

More Than Wrinkles: 5 Surprising Uses for Botox

22 June 2022


Botox/ Botulinum toxin- To most of us, Botox might be most famous as a neurotoxin injection for erasing wrinkles, but did you know that Botulinum toxin has far more medical applications? Botox (botulinum toxin) has received US FDA approval for treatment of forehead frown lines, glabella wrinkles and crows’ feet wrinkles. However, did you know that Botox is also US FDA approved for treating hyperhidrosis (excessive sweating), overactive bladders and neck spasms?


In my last blogpost, I shared about one novel use of shoulder botox injections for shoulder slimming in South Korea. Today’s review on Botox injections will look at more surprising uses for botulinum toxin- from calf slimming to neck to protecting your teeth.


These treatments are considered to be off-label use of Botox injections; which means that Botulinum toxin is used for a condition other than what the US FDA approved it for. This does not mean that Botox injections in these cases are unapproved; it only means that the safety and efficacy of Botulinum toxin in these instances have not been fully established. Always remember that if you are seeking Botulinum toxin injections in Singapore, please choose a qualified and experienced doctor to ensure your safety and minimal risk of side effects.


Besides removing wrinkles and body contouring, there are many more uses for Botulinum toxin in Singapore. Some of these indications for Botulinum toxin are considered ‘off-label’.


What does ‘off-label’ use of Botulinum toxin/ Botox mean?

Off-label use of medications also does not mean that the use is illegal; in fact there are many common medications that have been used off-label. Once a drug has received US FDA approval for a condition, licensed doctors are allowed to prescribe the drug for medical issues that they think might benefit the patient. For example, Propanolol, a medication for treating hypertension, is used off-label to treat a complication of hyperthyroidism called thyroid storm. Another example would be the off-label use of antibiotics to treat rosacea.


Related blogposts:

Rosacea: Symptoms, Triggers and Treatments

5 Skincare Tips for Sensitive Skin and Rosacea


As with any medical treatment, it’s always best to consult your doctor about the safety and suitability before proceeding with Botox injections. If you would like to read more about how Botox works and the safety concerns surrounding Botulinum toxin, this blogpost Is Botox Deadly? 5 Things You Need to Know About Botulinum Toxin Safety will discuss the safety, side effects and complications of Botox.


Here are 5 surprising off-label uses for Botulinum toxin injections in Singapore:



1. Botox Lip Flip/ Lip Lift

Before Kylie Jenner made full (some might say overdone) lips in vogue, Angeline Jolie’s iconic pout was widely coveted. Lip fillers have been the treatment of choice to plump up lips. Fillers used for lips are typically soft gels that contain hyaluronic acid which immediately add volume to thin lips. The downside of lip fillers? The dreaded duck lips or trout pouts look and lumpiness in the lips.


There are distinct differences in facial characteristics between Asians and Caucasians. Anthropological studies have shown that Chinese women have thicker upper and lower lips compared to their Caucasian counterparts1. Lip preferences also differ for different ethnic and cultural backgrounds. Although ideal facial dimensions cannot be generalised, it has also been shown Asians prefer smaller and thinner lips.


In the Botox Lip Flip (sometimes also referred to as the Botox Lip Lift), botulinum toxin is injected into the muscles around the mouth (orbicularis oris muscles) to relax the muscle and flips the corners of the lip upwards. The lip flip gives the illusion of slightly fuller lips without actually adding volume into the lip.


The results with the Botox Lip Flip are also more subtle than lip fillers. If you’re considering less options that are less invasive than lip fillers for lip augmentation; the Botox Lip Flip is an alternative.


Victoria Beckham slaying with her toned legs.


2.  Calf Slimming i.e. Calf Reduction Botox

Another off-label treatment for Botulinum toxin is the slimming of bulky calf muscles. Botox injections have been used to contour the leg muscles by causing controlled atrophy of the gastrocnemius muscle. An enlarged gastrocnemius muscle causes the calves to look bulky. Hence, by relaxing the gastrocnemius muscle with Botulinum toxin, muscles slim down for slimmer looking calves. The ideology of this is similar to Jaw botox for slimming down the sides of the face and trapezius muscle botox injections to slim down the shoulders.


Related blogposts:

Jaw Reduction Botox and Chin Filler Review

Shoulder Contouring with Trapezius Botox Injections



The bust of Queen Nefertiti. She was renowned for her beauty. Her long, slender neck and sharp jawline are immortalised in the Bust of Nefertiti.



3. The Nefertiti Lift

Queen Nefertiti was one of Egypt’s most famous queens renowned for her beauty. She was known as ‘Beauty of the Nile’ and her looks have been immortalised in a famous bust that depicted her delicate neck, slim jawline and arresting facial features.


The Nefertiti Lift is a non-invasive treatment that lifts and recontours sagging, banding and crepe-y skin along the jawline and neck. Small doses of botulinum toxin are injected into the platysmal muscle bands of the neck (i.e. turkey neck) and along the jaw to lift and tighten the skin and muscles. This also gives the neck and jawline a sharper and slimmer silhouette a la Nefertiti.


The Nefertiti Lift can be combined with Dermalift, where Microbotox is used to lift the skin. The results of this combination are very convincing and it’s what I’d recommend if you’re not ready for a face or neck threadlift.


Related blogposts:

Neck threadlifts in Double Chins Gone Forever

Is Profhilo the Injectable Skincare of the Future?


Model Chrissy Teigen sharing her experience getting underarm botox for hyperhidrosis on her Instagram stories.


4. Hyperhidrosis (Excessive sweating)

Excessive sweating is a medical condition called hyperhidrosis. Botulinum toxin blocks neurotransmission to sweat glands to reduce sweating. Botox has received US FDA approval for treatment of axillary hyperhidrosis in 2004; however treatment of excessive sweating in the hands and feet with Botulinum toxin is off-label.


Some of the non-surgical treatments for a slimmer nose are nose thread lifts, nose fillers and botulinum toxin.


5. Botox for a slimmer nose


Non-surgical nose enhancement is a popular request in Singapore. Nose thread lifts and nose fillers are two common options for achieving a slimmer nose bridge and nose tip.


However, if you have a wide nose due to nostril flaring when you laugh or smile, Botox can relax the muscle that widens your nostrils- the dilator nasalis muscle. By injecting botulinum toxin into this muscle, the sideways pulling action of the nose is lessened.


Related blogposts:

Hiko Nose Thread Lift: All You Need to Know

5 Things You Need to Know About Nose Fillers

Botox vs Fillers: Differences, Effects and Myomodulation



Conclusion on off-label uses for Botulinum toxin

There’s a lot more to Botox than removing wrinkles. Some of these uses for Botox are considered as off-label as US FDA approval has not been given yet. If you enjoyed this review on off-label uses of Botox, you might enjoy the following Botox related blogposts:

Too Much Botox: Botox Gone Wrong

Bruxism: Causes, Symptoms and Treatments

Preventive Botox and Baby Botox in Your 20’s Is Real

NoTox: Non-Invasive Botox Alternatives



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